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Literature summary extracted from

  • Bonnart, C.; Deraison, C.; Lacroix, M.; Uchida, Y.; Besson, C.; Robin, A.; Briot, A.; Gonthier, M.; Lamant, L.; Dubus, P.; Monsarrat, B.; Hovnanian, A.
    Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing (2010), J. Clin. Invest., 120, 871-882.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.71 kallikrein 5 kallikrein 5 leads to an elastolytic activity increase of 4times compared with the basal activity level of pro-ELA2 Mus musculus
3.4.21.71 kallikrein 5 kallikrein 5 leads to an elastolytic activity increase of 4times compared with the basal activity level of pro-elastase 2 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.71 secretory leukoprotease inhibitor
-
 Homo sapiens
3.4.21.71 secretory leukoprotease inhibitor
-
 Mus musculus
3.4.21.71 skin-derived antileukoprotease
-
 Homo sapiens
3.4.21.71 skin-derived antileukoprotease
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.71 (pro)-filaggrin + H2O Mus musculus direct degradation ?
-
 ?
3.4.21.71 (pro)-filaggrin + H2O Homo sapiens direct degradation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.71 Homo sapiens
-
-
-
3.4.21.71 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.71 epidermis localized to keratohyalin granules Mus musculus
-
3.4.21.71 epidermis localized to keratohyalin granules Homo sapiens
-
3.4.21.71 keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.71 (pro)-filaggrin + H2O direct degradation Mus musculus ?
-
 ?
3.4.21.71 (pro)-filaggrin + H2O direct degradation Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.71 ELA2
-
 Mus musculus
3.4.21.71 ELA2
-
 Homo sapiens
3.4.21.71 Elastase 2
-
 Mus musculus
3.4.21.71 Elastase 2
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.71 0.0000143
-
 skin-derived antileukoprotease pH and temperature not specified in the publication Homo sapiens
3.4.21.71 0.0000299
-
 secretory leukoprotease inhibitor pH and temperature not specified in the publication Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.71 physiological function elastase 2 impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. The enzyme is a major protease driving the pathogenesis of Netherton syndrome Homo sapiens
3.4.21.71 physiological function elastase 2 impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. The enzyme is a major protease driving the pathogenesis of Netherton syndrome. Transgenic elastase 2 mice display an ichthyotic phenotype Mus musculus